Last-Resort Drugs Breached by Antibiotic Resistance, Threatening Future of Medicine

A New Study which covers the Dangers From Resistance to Antibiotic Medication has become a serious matter to Health practitioners which lead to the Warning of it.

A gene that renders bacteria resistant to a group of powerful antibiotics known as polymyxins has emerged in farm animals and people in southern China, according to a report published online November 18, 2015, in the journal The Lancet Infectious Diseases. The gene,mcr-1, was discovered in three different bacterial species, including Escherichia coli, in extrachromosomal genetic elements known as plasmids, which are readily exchanged between bacterial cells to enable the spread of newly acquired traits.

The development ofmcr-1plasmid-mediated resistance in China is suspected to have been fueled by the overuse of colistin, a polymyxin antibiotic widely used in farm animals. In the new study, about 15 percentofE. coliisolates from raw pork and chicken, 21 percent from animals, and 1 percent from hospital patients in southern China were found to carrymcr-1.

Experts are concerned that the gene will soon spread from the region. Polymyxins are the last group of antibiotics to succumb to plasmid-mediated resistance, leaving medicine defenseless against pan-drug-resistant bacteria—organisms that evade every antibiotic available. The World Health Organization has warned that global medicine is nearing a post-antibiotic era, a future in which common once-treatable infections are deadly.

Since the mid-20th century, when antibiotic drug discovery peaked, only two new classes of antibiotics have reached the market, and antibiotic use worldwide has soared. Experts fear that without new antibiotics and increased diligence to prevent the overuse of existing drugs, the post-antibiotic era could be apocalyptic for modern medicine.

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